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Membrane biophysics

Liposome trapping processes by tumor origin cell lines

In this project we want to identify specific receptors to increase the trapping percentage of liposomes. Additionally, we are interested in analyzing how the liposome-membrane composition regulates catch and release processes of the liposomal content in tumor origin cell lines.

Estudio deStudy of survival strategies of S. aureus biofilms exposed to membrane-active antimicrobial peptides

The action mechanism of antimicrobial peptides results in the destabilization of the biofilm structure. Biofilm sections are affected in different ways by the action of antimicrobial peptides, depending on the exposure of cells to the peptide. Usingconfocal microscopy, we want to determine the biofilm section that presents the greatest damage due to peptide activity, as well as defining sub-populations within the biofilm that show the greatest susceptibility to the antimicrobial peptide.

Membrane fluctuation analysis in giant unilamelar vesicles

Membranes are essential constituents of any living organism. Their mechanical properties determine diverse aspects of physiological importance for the cell, such as stability and external factor resistance. Using Vesicle Fluctuation Analysis (VFA), one can infer the bending elastic constant and the rigidity of lipid membranes. We are interested in studying the changes in these constants under different conditions, such as the presence of charges or cholesterol.

Relation between membrane lipid composition and antimicrobial peptide susceptibility in S. aureus

Membranes affects membrane fluidity and modifies antimicrobial peptide susceptibility. Bacteria have the capacity of modifying lipid composition to adapt to new growth conditions. We are interested in knowing the membrane lipid composition in biofilms and the susceptibility to different antimicrobial peptides. 

Molecular dynamics of membranes to study their mechanical properties

We have developed a molecular dynamics technique to determine the elastic properties of different lipid systems. We use umbrella sampling to determine the Potential Mid Force (PMF) and to study deformation profiles in order to understand how the presence of different membrane modifiers (lisolipids, detergents, peptides) affect these mechanical properties.

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 Carrera 1 # 18-10

      Building Q, Laboratory 401/505

      Universidad de Los Andes

      Bogotá, Colombia

 (+57 1) 3394949

      Ext: 3783, 2703, 2621,5179

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